Home > acupuncture, Common Disease, Research > Acupuncture and Arthritis _ Recent Research Findings
Oct
15

ACUPUNCTURE FOR HIP AND KNEE ARTHRITIS
A large German trial has found that acupuncture is of significant benefit in controlling the pain of osteoarthritis of the hip and knee. Of 3633 patients, 357 were randomised to receive acupuncture (15 treatments over three months), 355 were randomised to a non-acupuncture control group, and 2921 did not accept randomisation and opted for acupuncture treatment. All patients received usual medical care in addition to acupuncture. The randomised acupuncture group showed significant improvement over controls at both three and six months in osteoarthritis severity (WOMAC scale) and quality of life. Improvements were comparable to those in the non randomised acupuncture group. The authors report that ” P h y s i c i a n c h a r a c t e r i s t i c s , s u c h a s t h e l e v e l o f f o r m a l a c u p u n c t u r e t r a i n i n g o r c e r t i f i c a t i o n , d i d n o t i n f l u e n c e t r e a t m e n t o u t c o m e s ” , although only 140 hours of certified training was a minimum requirement of participating physicians. Partly as a result of this trial, the German Ministry of Health is considering a recommendation from a federal committee of doctors and health insurers that acupuncture should be covered by medical insurance. (Acupuncture in patients with osteoarthritis of the knee or hip: A randomized, controlled trial with an additional nonrandomized arm. Arthritis & Rheumatism, 54; 11: 3485 – 3493).

ACUPUNCTURE & RHEUMATOID ARTHRITIS
A small study has demonstrated that acupuncture, and particularly electro-acupuncture, appears to be effective in reducing joint pain, stiffness and swelling in rheumatoid arthritis (RA). 36 patients, average age 58, suffering from RA that was unresponsive to other therapies, were assigned to three groups and received either electro-acupuncture, traditional acupuncture or ‘placebo acupuncture’. All received twenty treatments over ten weeks. The points used in the first two groups were Yangchi SJ-4, Waiguan SJ-5, Yangxi L.I.-5, Wangu SI-4, Dazhui DU-14 and Quchi L.I.-11. A total of 29 patients completed the study and most of the drop-outs (because of inefficacy) were in the placebo group. In both the acupuncture groups the number of tender joints and physician’s global scores were significantly reduced. (Efficacy of Traditional Chinese Acupuncture in the Treatment of Rheumatoid Arthritis (RA): A Double-blind Controlled Pilot Study. American College of Rheumatology Annual Scientific Meeting, November 2006).

ACUPUNCTURE & KNEE OSTEOARTHRITIS
Another German trial has shown a significant benefit for acupuncture treatment (in this case in the treatment of osteoarthritis of the knee), yet with no significant difference between true and sham acupuncture. In this large trial of 1007 patients (treated by 320 different practitioners in 315 primary care practices), who had had chronic pain from knee arthritis for over six months, a minimum 36% improvement was seen at 26 weeks (after ten acupuncture treatments) in 53.1% of true acupuncture patients, 51.0% of sham acupuncture patients and 29.1% for patients receiving conservative therapy (standard physician visits). This batch of German studies raises important questions for acupuncturists. While some attention has been focused on what might be the physiological effects of sham needling (usually very superficial insertion at non-points with no deqi), it is also necessary to examine the true acupuncture, and specifically how effectively practitioners succeeded in obtaining deqi, which was a necessary part of the true acupuncture protocol. (Acupuncture and Knee Osteoarthritis: A Three-Armed Randomized Trial, Annals of Internal Medicine, 4 July 2006).

ACUPUNCTURE EFFECTIVE FOR KNEE ARTHRITIS
In a study of the treatment of chronic arthritis of the knee, 150 patients were assigned to receive ‘true’ acupuncture, 76 to minimal acupuncture (superficial needling at non-acupuncture points) and 76 to a waiting list control. Both acupuncture groups received 12 treatment sessions over 8 weeks at 28 different outpatient centres. Patients completed standard questionnaires at 8, 26 and 52 weeks after onset of treatment. The study found that patients in both acupuncture groups improved compared to a waiting list group, but that those receiving true acupuncture suffered significantly less pain and joint dysfunction at 8 weeks than the sham acupuncture group. The difference was no longer significant, however, at 52 weeks. (The Lancet 2005; 366:136-143).

ACUPUNCTURE & KNEE ARTHRITIS
The longest and largest randomised, controlled phase III clinical trial of acupuncture ever conducted has found that acupuncture can significantly improve the symptoms of arthritis of the knee. The study of 570 patients was carried out at the University of Maryland School of Medicine. The patients were randomly assigned to receive 23 treatments of either true or sham (no actual insertion of needles) acupuncture or a 12-week knee osteoarthritis education course. At the end of the study, the true acupuncture group had the greatest reduction (40%) in knee pain and the greatest improvement (nearly 40%) in knee function. The study was funded by the National Center for Complementary and Alternative Medicine (NCCAM) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), both components of the US National Institutes of Health. “For the first time, a clinical trial with sufficient rigour, size, and duration has shown that acupuncture reduces the pain and functional impairment of osteoarthritis of the knee,” said Stephen E. Straus, NCCAM Director. “These results also indicate that acupuncture can serve as an effective addition to a standard regimen of care and improve quality of life for knee osteoarthritis sufferers. (Ann Intern Med, Dec 2004; 141: 901-910.)

ACUPUNCTURE & KNEE ARTHRITIS
In a separate Spanish study of the potential benefits of acupuncture in the treatment of knee osteoarthritis, 97 patients were randomly assigned to receive either acupuncture plus diclofenac, or placebo acupuncture plus diclofenac. The true acupuncture consisted of needling (followed by electroacupuncture at the local points) at Yanglingquan GB-34, Yinlingquan SP-9, Xiyan (MN-LE-16), Zusanli ST-36, Taixi KID-3, Sanyinjiao SP-6, Hegu L.I.-4 and Fenglong ST-40 (all with deqi). The placebo acupuncture was administered using retractable needles (with adhesive cylinders) at the same points, and sham electroacupuncture was also given. Both groups received twelve weekly treatments. At the end of the study, the true acupuncture group had a greater reduction in pain and stiffness, improved physical functioning, and an improved quality of life. (BMJ 2004;329:1216).ACUPUNCTURE FOR NECK PAIN
This very large German study compared the effects of fifteen acupuncture treatments over three months with no acupuncture in the treatment of chronic neck pain (longer than six months). 1753 patients were randomly allocated to receive acupuncture and 1698 to the non-acupuncture control group, and a further 10,395 patients rejected randomisation and elected to receive acupuncture. At the end of the three-month treatment period, chronic pain and disability scores and quality of life scores improved significantly in both acupuncture groups compared to controls, with no significant differences between the randomised and non-randomised acupuncture groups. (11th Annual Symposium on Complementary Health Care 2004).

ACUPUNCTURE FOR OSTEOARTHRITIS OF THE KNEE
30 patients with osteoarthritis of the knee were randomised to one of three groups: 1. acupuncture alone at Hegu L.I.-4, Xuehai SP-10, Xiyan (MN-LE-16), Yinlingquan SP-9, Yanglingquan GB-34, Zusanli ST-36, Taichong LIV-3, Weizhong BL-40 and Chengshan BL-57 (twice weekly treatment, obtaining of deqi, 10 treatments in total, using electro-acupuncture at most points); 2. identical acupuncture plus continuation of their symptomatic Western medication; 3. symptomatic medication alone for five weeks, followed by a course of acupuncture as above. Outcome measures (visual analogue pain scale/VAS and Western Ontario McMaster questionnaire/WOMAC) were administered by a blinded observer. Highly significant improvements in both measures were observed in the first two groups, and there was no change in the third group until they received acupuncture, when significant changes were observed. The benefits were maintained one month after the end of the course of acupuncture. (Acupuncture in Medicine 2004;22(1):14-22). In another study, 563 patients with arthritis of the knee (54% of 5-10 year duration; 23% more than 10 years) were treated with acupuncture for a maximum of 15 sessions, with treatment cessation if no improvement was noted after three treatments (these patients were included in the study results). Of the 85% of patients who completed treatment (standard points and additional points according to TCM pattern, with deqi, average 8.9 sessions per patient), 75% experienced a greater than 45% relief in pain scores. There was a significant difference in quantity of analgesics taken at completion of treatment (most of the 45% pain-relief responders ceased medication entirely). Cost analysis showed a reduction from a mean of .91 euros a day before treatment, to .18 euros a day after treatment, representing a daily saving of 349.50 euros a day for the 478 patients who stayed in the study. (Acupuncture in Medicine 2004;22(1):23-28).

LEI GONG TENG & RA
A root extract of Lei Gong Teng (Tripterygium Wilfordii Hook) has been shown to safely and effectively reduce pain and inflammation in a randomised, double-blind, placebo-controlled trial of a small group of people with treatment-resistant rheumatoid arthritis (RA). In the 20-week clinical trial, 21 RA patients were randomly assigned to one of three treatment groups: placebo, low-dose extract, or high-dose extract. After four weeks, 80% of patients in the high-dose group and 40% in the low-dose group showed rapid improvement in symptoms compared with no improvement in the placebo group. Side effects were minor for all three treatment groups. According to the researchers Lei Gong Teng is unique, because it slows down the overactive immune system, reduces inflammation by turning off inflammatory genes such as tumour necrosis factor alpha, and reduces the activity of B and T cells. It has the potential to treat other immune diseases such as lupus, and further studies are planned. The extraction process used in the trial transforms the otherwise toxic Lei Gong Teng. (Arthritis & Rheumatism 2002;46(7):1735-43). Meanwhile Fujisawa Pharmaceutical, the Japanese company who manufacture Prograf, a prescription medicine used to prevent the immune system from rejecting transplants, has entered into collaboration with Pharmagenesis, the US company which develops pharmaceuticals derived from Chinese herbal medicines, to explore triptolide derivatives, novel and potent immunosuppressants created by Pharmagenesis from Lei Gong Teng. Triptolide and its derivatives inhibit cytokine production in T cells through a different mechanism of action from Prograf and are expected to be effective in prevention of acute and chronic rejection for patients undergoing organ transplants.

ACUPUNCTURE & KNEE OSTEOARTHRITIS
60 patients on a waiting list for total knee replacement were randomly divided into two groups. 30 received “medical acupuncture” using one inch needles inserted “deeply” at Yinlingquan SP-9, Xuehai SP-10, Liangqiu ST 34, Zusanli ST-36 and Hegu L.I.-4. The needles were manipulated manually 4 times during a 15 minute retention and patients received a total of 6 weekly treatments. The 30 patients in the control group received no treatment. At a 2-month follow up, scores for the time to walk 50 metres and the time to climb 20 steps fell significantly in the acupuncture group compared to the control, as did pain scores, whilst HSS knee scores – which gives marks for pain, functional ability, range of motion, muscle strength, flexion deformity and knee stability – improved significantly in the acupuncture group. Scores for all measures deteriorated in the non-treatment group. 3 patients in the acupuncture group requested suspension from the waiting list due to the improvement in their symptoms. (Acupunct Med 2002; 20(1): 19-21).

ACUPUNCTURE & OSTEOARTHRITIS OF THE KNEE
44 patents with advanced osteoarthritis of the knee who were awaiting total knee joint replacements were given acupuncture either on the most affected knee only, or on both knees. Points needled were Yinlingquan SP-9, Xuehai SP-10, Liangqiu ST-34, Zusanli ST-36 and Hegu L.I.-4. Results showed a significant reduction in symptoms in both groups with no signficant dfference between the two groups, suggesting hat unilateral acupuncture is as effective as bilateral acupuncture for this condition. (Acupuncture in Medicine 2001;19(1):15-18).

OSTEOARTHRITIC HYPEROSTOSIS
It is estimated that the majority of the over-50’s in the USA have osteoarthritic bony hypertrophy (osteophytes), with the disease present in 90% of 80-year olds. In a study carried out at Guangzhou Hospital of TCM, 183 patients were treated by warm needling (Shenshu BL-23, Pangguangshu BL-28, Yaoyangguan DU-3 plus Weizhong BL-40 for cold-damp type and Taixi KID-3 for Kidney deficient type) followed by cupping to the lumbo-sacral area. After treatment, although x-rays showed no change to the degree of bony malformation, the symptoms of 48% of patients were cured and 50% were improved (American Journal of Acupuncture Vol.24, No.1).

, , ,

Add reply

You must be logged in to post a comment.